Conference Series LLC Ltd invites the contributors across the globe to participate in the premier “CRISPR-2018”, to discuss the theme: “CRISPR technology to feed, fuel and heal the world”. The conference will be held in Boston, USA during October 19-20, 2018 wherein prompt keynote presentations, Oral talks, Poster presentations and Exhibitions are included.
“CRISPR” (pronounced “crispr”) stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the hallmark of a bacterial defense system that forms the basis for CRISPR-Cas9 genome editing technology. In the field of genome engineering, the term “CRISPR” or “CRISPR-Cas9” is often used loosely to refer to the various CRISPR-Cas9 and -CPF1, (and other) systems that can be programmed to target specific stretches of genetic code and to edit DNA at precise locations, as well as for other purposes, such as for new diagnostic tools. With these systems, researchers can permanently modify genes in living cells and organisms and, in the future, may make it possible to correct mutations at precise locations in the human genome in order to treat genetic causes of disease. Other systems are now available, such as CRISPR-Cas13’s, that target RNA provide alternate avenues for use, and with unique characteristics that have been leveraged for sensitive diagnostic tools, such as SHERLOCK.
CRISPR genome editing allows scientists to quickly create cell and animal models, which researchers can use to accelerate research into diseases such as cancer and mental illness. In addition, CRISPR is now being developed as a rapid diagnostic.
Studies using in vitro (laboratory) and animal models of human disease have demonstrated that the technology can be effective in correcting genetic defects. Examples of such diseases include cystic fibrosis, cataracts, and Fanconi anemia, according to a 2016 review article published in the journal Nature Biotechnology. These studies pave the way for therapeutic applications in humans.
CRISPR technology has also been applied in the food and agricultural industries to engineer probiotic cultures and to vaccinate industrial cultures (for yogurt, for example) against viruses. It is also being used in crops to improve yield, drought tolerance and nutritional properties.
One other potential application is to create gene drives. These are genetic systems, which increase the chances of a particular trait passing on from parent to offspring.
However, CRISPR-Cas9 is not without its drawbacks.
The genome-editing efficiencies can vary. According to the 2014 Science article by Doudna and Charpentier, in a study conducted in rice, gene editing occurred in nearly 50 percent of the cells that received the Cas9-RNA complex. Whereas other analyses have shown that depending on the target, editing efficiencies can reach as high as 80 percent or more.
There is also the phenomenon of “off-target effects,” where DNA is cut at sites other than the intended target. This can lead to the introduction of unintended mutations.
International conference of CRISPR-2018 is a Research-scientific knowledge bridge, that aims bring together multi-disciplinary luminaries for Thriving innovation in the Biotechnology. The scientific conferences have been carefully structured so as to share knowledge and thoughts through presentations and exhibitions. CRISPR-2018 event with sessions covers all aspects of biotech-driven technique CRISPR and addresses the key issues currently affecting its researches. Attendees can look forward to hearing about the different strategies taken to improve ongoing research and decipher how to overcome technical limitations in research development. This conference is where pharm, investors and Life Science companies find partners, access innovation, find funding and brainstorm the solutions to further their business needs.